Studying Variations in Bone Composition at Nano-Scale Resolution: A Preliminary Report

被引：25

作者：

Gourion-Arsiquaud, Samuel ^{[1
]}

Marcott, Curtis ^{[2
]}

Hu, Qichi ^{[3
]}

Boskey, Adele L. ^{[4
]}

机构：

[1] TRI Princeton, Princeton, NJ USA

[2] Light Light Solut, Athens, GA USA

[3] Anasys Instruments, Santa Barbara, CA USA

[4] Hosp Special Surg, Mineralized Tissue Lab, New York, NY 10021 USA

来源：

CALCIFIED TISSUE INTERNATIONAL | 2014年 / 95卷 / 05期

基金：

美国国家科学基金会;

关键词：

AFM-IR; Nano-IR; Bone composition; Osteonal bone; Bone nano-structure; ZOLEDRONIC ACID; ILIAC CREST; WOMEN; MINERALIZATION; HETEROGENEITY; BIOPSIES; QUALITY; MATRIX; TISSUE; RAMAN;

D O I：

10.1007/s00223-014-9909-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone has a hierarchical structure extending from the micrometer to the nanometer scale. We report here the first analysis of non-human primate osteonal bone obtained using a spectrometer coupled to an AFM microscope (AFM-IR), with a resolution of 50-100 nm. Average spectra correspond to those observed with conventional FTIR spectroscopy. The following validated FTIR parameters were calculated based on intensities observed in scans covering similar to 60 A mu m from the osteon center: mineral content (1030/1660 cm(-1)), crystallinity (1030/1020 cm(-1)), collagen maturity (1660/1690 cm(-1)), and acid phosphate content (1128/1096 cm(-1)). A repeating pattern was found in most of these calculated IR parameters corresponding to the reported inter- and intra-lamellar spacing in human bone, indicating that AFM-IR measurements will be able to provide novel compositional information on the variation in bone at the nanometer level.

引用

页码：413 / 418

页数：6

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