Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia

被引：2
|
作者：
Kisrieva, Yu. S. [1 ]
Petushkova, N. A. [1 ]
Samenkova, N. F. [1 ]
Kuznetsova, G. P. [1 ]
Larina, O. V. [1 ]
Teryaeva, N. B. [2 ]
Zgoda, V. G. [1 ]
Karuzina, I. I. [1 ]
Usachev, D. U. [2 ]
Belyaev, A. Yu. [2 ]
机构：
[1] VN Orekhovich Res Inst Biomed Chem, Moscow, Russia
[2] Minist Hlth Russian Federat, NN Burdenko Natl Res & Pract Ctr Neurosurg, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
cerebral ischemia; blood plasma proteome; liquid chromatography-mass spectrometry; APOPTOSIS; PHOSPHORYLATION;
D O I：
10.1007/s10517-018-4090-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
引用
收藏
页码：22 / 26
页数：5
相关论文
共 50 条
  • [41] Analysis　of　Plasma　Fibrinolysis　in　the　Patients　with　Acute　Cerebral　Infarction
    张颖冬
    刘锡民
    蔡转
    杨明山
    同济医科大学学报(外文版), 1995, (02) : 68 - 72
  • [42] Effects of cerebral ischemia on evoked cerebral blood oxygenation responses and BOLD contrast functional MRI in stroke patients
    Murata, Yoshihiro
    Sakatani, Kaoru
    Hoshino, Tatsuya
    Fujiwara, Norio
    Kano, Tsuneo
    Nakamura, Shin
    Katayama, Yoichi
    STROKE, 2006, 37 (10) : 2514 - 2520
  • [43] Protein aggregation and delayed neuronal death following transient cerebral ischemia. Cerebral ischemia
    Hu, B
    Martone, ME
    Liu, C
    JOURNAL OF NEUROCHEMISTRY, 2003, 87 : 8 - 8
  • [44] Temporal profile of plasma adiponectin level and delayed cerebral ischemia in patients with subarachnoid hemorrhage
    Takeuchi, Satoru
    Wada, Kojiro
    Otani, Naoki
    Osada, Hideo
    Nagatani, Kimihiro
    Mori, Kentaro
    JOURNAL OF CLINICAL NEUROSCIENCE, 2014, 21 (06) : 1007 - 1010
  • [45] Cerebral Ischemia in Patients on Direct Oral Anticoagulants Plasma Levels Are Associated With Stroke Severity
    Macha, Kosmas
    Marsch, Armin
    Siedler, Gabriela
    Breuer, Lorenz
    Strasser, Erwin F.
    Engelhorn, Tobias
    Schwab, Stefan
    Kallmuenzer, Bernd
    STROKE, 2019, 50 (04) : 873 - 879
  • [46] Middle cerebral artery fenestration in patients with cerebral ischemia
    Jeong, Seul-Ki
    Kwak, Hyo-Sung
    Cho, Young-Il
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 275 (1-2) : 181 - 184
  • [47] QUANTITATIVE MEASUREMENT OF CEREBRAL BLOOD-FLOW AND CEREBRAL BLOOD-VOLUME AFTER CEREBRAL-ISCHEMIA
    TODD, NV
    PICOZZI, P
    CROCKARD, HA
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1986, 6 (03): : 338 - 341
  • [48] NOCTURNAL BLOOD-PRESSURE INCREASE IN PATIENTS SUFFERING FROM CEREBRAL-ISCHEMIA
    SCHRADER, J
    DOUTHEIL, A
    SCHOEL, G
    HOLZGRAEFE, M
    HEYDENBLUTH, R
    FLEGENHAUER, K
    SCHELER, F
    KIDNEY INTERNATIONAL, 1993, 44 (01) : 246 - 246
  • [49] Effect of propentofylline on cerebral blood flow in a gerbil focal cerebral ischemia
    Turcáni, P
    Turèáni, M
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2001, 183 (01) : 57 - 60
  • [50] Elevated blood viscosity is associated with delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage
    Yi, Ho Jun
    Shin, Dong-Seong
    Kim, Bum -Tae
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2022, 31 (12):
12345