Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia

被引：2
|
作者：
Kisrieva, Yu. S. [1 ]
Petushkova, N. A. [1 ]
Samenkova, N. F. [1 ]
Kuznetsova, G. P. [1 ]
Larina, O. V. [1 ]
Teryaeva, N. B. [2 ]
Zgoda, V. G. [1 ]
Karuzina, I. I. [1 ]
Usachev, D. U. [2 ]
Belyaev, A. Yu. [2 ]
机构：
[1] VN Orekhovich Res Inst Biomed Chem, Moscow, Russia
[2] Minist Hlth Russian Federat, NN Burdenko Natl Res & Pract Ctr Neurosurg, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
cerebral ischemia; blood plasma proteome; liquid chromatography-mass spectrometry; APOPTOSIS; PHOSPHORYLATION;
D O I：
10.1007/s10517-018-4090-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
引用
收藏
页码：22 / 26
页数：5
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