Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia

被引：2
|
作者：
Kisrieva, Yu. S. [1 ]
Petushkova, N. A. [1 ]
Samenkova, N. F. [1 ]
Kuznetsova, G. P. [1 ]
Larina, O. V. [1 ]
Teryaeva, N. B. [2 ]
Zgoda, V. G. [1 ]
Karuzina, I. I. [1 ]
Usachev, D. U. [2 ]
Belyaev, A. Yu. [2 ]
机构：
[1] VN Orekhovich Res Inst Biomed Chem, Moscow, Russia
[2] Minist Hlth Russian Federat, NN Burdenko Natl Res & Pract Ctr Neurosurg, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 165卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
cerebral ischemia; blood plasma proteome; liquid chromatography-mass spectrometry; APOPTOSIS; PHOSPHORYLATION;
D O I：
10.1007/s10517-018-4090-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
引用
收藏
页码：22 / 26
页数：5
相关论文
共 50 条
  • [1] Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia
    Yu. S. Kisrieva
    N. A. Petushkova
    N. F. Samenkova
    G. P. Kuznetsova
    O. V. Larina
    N. B. Teryaeva
    V. G. Zgoda
    I. I. Karuzina
    D. U. Usachev
    A. Yu. Belyaev
    Bulletin of Experimental Biology and Medicine, 2018, 165 : 22 - 26
  • [2] Relative Abundance of Proteins in Blood Plasma Samples from Patients with Chronic Cerebral Ischemia
    Kaysheva, Anna L.
    Kopylov, Artur T.
    Ponomarenko, Elena A.
    Kiseleva, Olga I.
    Teryaeva, Nadezhda B.
    Potapov, Alexander A.
    Izotov, Alexander A.
    Morozov, Sergei G.
    Kudryavtseva, Valeria Yu.
    Archakov, Alexander I.
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2018, 64 (03) : 440 - 448
  • [3] Relative Abundance of Proteins in Blood Plasma Samples from Patients with Chronic Cerebral Ischemia
    Anna L. Kaysheva
    Artur T. Kopylov
    Elena A. Ponomarenko
    Olga I. Kiseleva
    Nadezhda B. Teryaeva
    Alexander A. Potapov
    Alexander А. Izotov
    Sergei G. Morozov
    Valeria Yu. Kudryavtseva
    Alexander I. Archakov
    Journal of Molecular Neuroscience, 2018, 64 : 440 - 448
  • [4] Mass Spectrometry Profiling of the Protein Composition of Blood Plasma of Colorectal Cancer Patients
    A. L. Kaysheva
    A. T. Kopylov
    T. O. Pleshakova
    N. E. Kushlinskii
    V. G. Nikitaev
    E. A. Druzhinina
    A. I. Archakov
    Yu. D. Ivanov
    Bulletin of the Lebedev Physics Institute, 2018, 45 : 279 - 281
  • [5] Mass Spectrometry Profiling of the Protein Composition of Blood Plasma of Colorectal Cancer Patients
    Kaysheva, A. L.
    Kopylov, A. T.
    Pleshakova, T. O.
    Kushlinskii, N. E.
    Nikitaev, V. G.
    Druzhinina, E. A.
    Archakov, A. I.
    Ivanov, Yu. D.
    BULLETIN OF THE LEBEDEV PHYSICS INSTITUTE, 2018, 45 (09) : 279 - 281
  • [6] Effect of ibudilast on non-specific symptoms in patients with chronic cerebral ischemia - Analysis of cerebral blood flow
    Inoue, Nobuhiro
    Harada, Mikio
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2008, 58 (06): : 277 - 282
  • [7] Threshold of regional cerebral blood flow for infarction in patients with acute cerebral ischemia
    Ohashi, M
    Tsuji, A
    Kaneko, M
    Matsuda, M
    JOURNAL OF NEURORADIOLOGY, 2005, 32 (05) : 337 - 341
  • [8] CEREBRAL BLOOD-FLOW AND CEREBRAL HEMATOCRIT IN PATIENTS WITH CEREBRAL-ISCHEMIA MEASURED BY SPECT
    SAKAI, F
    CLINICAL HEMORHEOLOGY, 1987, 7 (03): : 538 - 538
  • [9] Emotional Stress in Rats Changes Concentration and Composition of Extracellular DNA Circulating in Blood Plasma under Normal Conditions and in Cerebral Ischemia
    I. L. Konorova
    N. N. Veiko
    Bulletin of Experimental Biology and Medicine, 2012, 153 : 305 - 308
  • [10] Emotional Stress in Rats Changes Concentration and Composition of Extracellular DNA Circulating in Blood Plasma under Normal Conditions and in Cerebral Ischemia
    Konorova, I. L.
    Veiko, N. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 153 (03) : 305 - 308
12345