Two new phenolic compounds from the white flower of Impatiens balsamina

During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1-2) containing a nitrile group and eleven known phenolic compounds (3-13) were isolated. The chemical structures of new compounds (1-2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1-13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.