Two new phenolic compounds from the white flower of Impatiens balsamina

被引：16

作者：

Kim, Chung Sub ^{[1
]}

Subedi, Lalita ^{[2
,3
]}

Kim, Sun Yeou ^{[2
,3
]}

Choi, Sang Un ^{[4
]}

Choi, Sang Zin ^{[5
]}

Son, Mi Won ^{[5
]}

Kim, Ki Hyun ^{[1
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 16419, South Korea

[2] Gachon Univ, Gachon Inst Pharmaceut Sci, Inchon 21936, South Korea

[3] Gachon Univ, Coll Pharm, Inchon 21936, South Korea

[4] Korea Res Inst Chem Technol, Daejeon 34114, South Korea

[5] Dong A ST Res Inst, Kiheung 17073, Yongin, South Korea

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 14卷

关键词：

Impatiens balsamina; Balsamineaceae; Phenolic compounds; Cytotoxicity; Neuroprotection; Anti-neuroinflammation; ANTIOXIDANT; DERIVATIVES; GLYCOSIDES; MICROGLIA; EFFICIENT; ACID; L;

D O I：

10.1016/j.phytol.2015.10.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

During the course of our continuing search for biologically active compounds from Korean medicinal sources, we investigated the white flower of Impatiens balsamina. From the MeOH extract, two new phenolic compounds (1-2) containing a nitrile group and eleven known phenolic compounds (3-13) were isolated. The chemical structures of new compounds (1-2) were determined through NMR, HRMS, and CD data. We tested the isolated compounds (1-13) for their cytotoxic activities by determining their inhibitory effects on human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay. We also investigated their neuroprotective activity by determining their effects on nerve growth factor (NGF) secretion in C6 cells, and anti-neuroinflammatory activity by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV-2 cells. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：215 / 220

页数：6

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