Extraction and antioxidant activity of flavonoids of Morus nigra

被引：7

作者：

Feng, Rui-Zhang ^{[1
]}

Wang, Qin ^{[2
]}

Tong, Wen-Zhi ^{[2
]}

Xiong, Juan ^{[2
]}

Wei, Qin ^{[1
]}

Zhou, Wan-Hai ^{[1
]}

Yin, Zhong-Qiong ^{[2
]}

Yin, Xiao-Ya ^{[2
]}

Wang, Li-Ying ^{[2
]}

Chen, Ya-Qin ^{[2
]}

Lai, Yong-Hong ^{[2
]}

Huang, Hong-Yan ^{[2
]}

Luo, Qiao-Li ^{[2
]}

Wang, Lu ^{[2
]}

Jia, Ren-Yong ^{[3
]}

Song, Xu ^{[2
]}

Zou, Yuan-Feng ^{[2
]}

Li, Li-Xia ^{[2
]}

机构：

[1] Yibin Univ, Key Lab Aromat Plant Resources Exploitat & Utiliz, Yibin 644000, Peoples R China

[2] Sichuan Agr Univ, Coll Vet Med, Nat Med Res Ctr, Chengdu 611130, Peoples R China

[3] Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Morus nigra; total flavonoids; antioxidant activity; ALBA; RUBRA;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Morus nigra has a long history of medicinal use in Chinese medicine, but the study on it is limited, the flavonoids are one of the main biological active substances. In this study, the Morus nigra flavonoids were extracted by ultrasonic and antioxidant activities both in vitro and in vivo were measured. The results showed that hydroxyl radicals clearance rate and superoxide radical anion clearance rate in vitro increased with the concentration of the total flavonoids in the range of 0-1.05 mg/mL and the maximum clearance rate was 80.33% and 87.69%, respectively. After mice were treated with flavonoids, the content of malonaldehyde (MDA) in serum and liver decreased; the activities of superoxide dismutase (SOD) in serum and liver, catalase (CAT) in liver and glutathione peroxidase (GSH-PX) in blood and liver increased; Langhans cells increased in spleen. These results revealed that the Morus nigra flavonoids possessed strong antioxidant activity.

引用

页码：22328 / 22336

页数：9

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