KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis

被引：5
|
作者：
Goris, An [1 ]
Dobosi, Rita [1 ]
Boonen, Steven [2 ,3 ]
Nagels, Guy [4 ]
Dubois, Benedicte [1 ]
机构：
[1] Katholieke Univ Leuven, Sect Expt Neurol, Lab Neuroimmunol, B-3000 Louvain, Belgium
[2] Univ Leuven, Ctr Metab Bone Dis, B-3000 Louvain, Belgium
[3] Univ Leuven, Div Geriatr Med, B-3000 Louvain, Belgium
[4] Natl MS Ctr Melsbroek, B-1820 Melsbroek, Belgium
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 210卷 / 1-2期
关键词：
Multiple sclerosis; Natural killer cells; KIR2DL4; Association; Genetics; Autoimmunity; NATURAL-KILLER-CELLS; INTERLEUKIN-7; RECEPTOR; NK CELLS; ALLELES; RISK;
D O I：
10.1016/j.jneuroim.2009.03.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Several lines of evidence implicate CD56(bright) NK cells in the pathogenesis of multiple sclerosis (MS). This proposed immunoregulatory pathway involves already established susceptibility genes such as interleukin-2 receptor alpha (IL2RA) and interleukin-7 receptor (IL7R). We therefore investigated the CD56(bright) NK cell effector molecule KIR2DL4 for its involvement in genetic susceptibility to MS in a study population of 763 cases and 967 controls. Whereas 26% of the study population has a genotype corresponding to a lack of any functional membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane alleles with susceptibility to MS was observed. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：113 / 115
页数：3
相关论文
共 50 条
  • [41] COMPARISON OF THE KIR2DL4 TRANSCRIPTOME BETWEEN HUMANS, CHIMPANZEES AND OLD WORLD MONKEYS
    Heijmans, Corrine M. C.
    Bruijnesteijn, Jesse
    van der Wiel, Marit K. H.
    de Groot, Natasja G.
    Bontrop, Ronald E.
    HLA, 2019, 93 (05) : 285 - 286
  • [42] Identification of the novel KIR2DL4*040 allele in a southern Chinese Han individual
    Cai, S. -Q.
    Chen, R.
    Deng, Z. -H.
    HLA, 2018, 91 (03) : 226 - 227
  • [43] Identification of the novel KIR2DL4*00106 allele in a southern Chinese Han individual
    Wang, F.
    Cai, S. -Q.
    Yu, Q.
    HLA, 2018, 92 (03) : 187 - 188
  • [44] Description of the novel KIR2DL4*00603 allele identified in a Chinese Hani individual
    Su, Pincan
    Yang, Tonghua
    Ma, Haili
    Zhang, Guobin
    Deng, Zhi-Hui
    HLA, 2019, 94 (02) : 181 - +
  • [45] The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4
    Moradi, Shoeib
    Berry, Richard
    Pymm, Phillip
    Hitchen, Corinne
    Beckham, Simone A.
    Wilce, Matthew C. J.
    Walpole, Nicholas G.
    Clements, Craig S.
    Reid, Hugh H.
    Perugini, Matthew A.
    Brooks, Andrew G.
    Rossjohn, Jamie
    Vivian, Julian P.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (16) : 10460 - 10471
  • [46] Characterization of the novel KIR2DL4*037 allele identified in a Chinese Hani individual
    Su, Pincan
    Yang, Tonghua
    Ma, Haili
    Zhang, Guobin
    Deng, Zhi-Hui
    HLA, 2019, 94 (02) : 184 - 185
  • [47] Langerhans Cell Histiocytosis Expresses Killer Cell Immunoglobulin-Like Receptor 2DL4 (CD158d), a Possible Target of Antibody Therapy
    Kataoka, Tatsuki R.
    Ueshima, Chiyuki
    Hirata, Masahiro
    Takei, Yusuke
    Iwamoto, Sanju
    Haga, Hironori
    MODERN PATHOLOGY, 2016, 29 : 356A - 356A
  • [48] ITGA4 polymorphisms and susceptibility to multiple sclerosis
    O'Doherty, Catherine
    Roos, Izaura M.
    Antiguedad, Alfredo
    Aransay, Ana M.
    Hillert, Jan
    Vandenbroeck, Koen
    JOURNAL OF NEUROIMMUNOLOGY, 2007, 189 (1-2) : 151 - 157
  • [49] Allelic polymorphism and haplotypic associations of KIR2DL4, 3DL1 and 3DL2 genes in 77 Korean families
    Park, Myoung Hee
    Yoon, Jun Ah
    Park, Soyun
    Park, KyungSook
    HUMAN IMMUNOLOGY, 2006, 67 (10) : S108 - S108
  • [50] Identification of the novel KIR2DL4*00503 allele from a southern Chinese Han individual
    Chen, R.
    Zhang, G-B
    Deng, Z-H
    HLA, 2016, 88 (06) : 319 - 320
12345