KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis

被引：5

作者：

Goris, An ^{[1
]}

Dobosi, Rita ^{[1
]}

Boonen, Steven ^{[2
,3
]}

Nagels, Guy ^{[4
]}

Dubois, Benedicte ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Sect Expt Neurol, Lab Neuroimmunol, B-3000 Louvain, Belgium

[2] Univ Leuven, Ctr Metab Bone Dis, B-3000 Louvain, Belgium

[3] Univ Leuven, Div Geriatr Med, B-3000 Louvain, Belgium

[4] Natl MS Ctr Melsbroek, B-1820 Melsbroek, Belgium

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 210卷 / 1-2期

关键词：

Multiple sclerosis; Natural killer cells; KIR2DL4; Association; Genetics; Autoimmunity; NATURAL-KILLER-CELLS; INTERLEUKIN-7; RECEPTOR; NK CELLS; ALLELES; RISK;

D O I：

10.1016/j.jneuroim.2009.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several lines of evidence implicate CD56(bright) NK cells in the pathogenesis of multiple sclerosis (MS). This proposed immunoregulatory pathway involves already established susceptibility genes such as interleukin-2 receptor alpha (IL2RA) and interleukin-7 receptor (IL7R). We therefore investigated the CD56(bright) NK cell effector molecule KIR2DL4 for its involvement in genetic susceptibility to MS in a study population of 763 cases and 967 controls. Whereas 26% of the study population has a genotype corresponding to a lack of any functional membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane alleles with susceptibility to MS was observed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：113 / 115

页数：3

共 50 条

[31] Identification of novel ligand(s) for the NK cell receptor, KIR2DL4
Brusilovsky, Michael
Porgador, Angel
Campbell, Kerry
JOURNAL OF IMMUNOLOGY, 2010, 184
[32] Possible roles of KIR2DL4 expression on uNK cells in human pregnancy
Yan, Wei-hua
Lin, Aifen
Chen, Bao-guo
Zhou, Mei-ying
Dai, Mei-zhen
Chen, Xue-jiao
Gan, Ling-hong
Zhu, Min
Shi, Wei-wu
Li, Bo-li
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2007, 57 (04) : 233 - 242
[33] THE ASSOCIATION OF KIR2DL4, LILRB HAPLOTYPES AND THEIR LIGAND HLA-G WITH ENDOMETRIOSIS
Bylinska, Aleksandra
Wilczynska, Karolina
Wisniewski, Andrzej
Malejczyk, Jacek
Milewski, Lukasz
Wagner, Marta
Jasek, Monika
Niepieklo-Miniewska, Wanda
Ploski, Rafal
Barcz, Ewa
Roszkowski, Piotr
Kaminski, Pawel
Malinowski, Andrzej
Wilczynski, Jacek
Radwan, Pawel
Radwan, Michal
Kusnierczyk, Piotr
Nowak, Izabela
HLA, 2018, 91 (05) : 464 - 464
[34] Cloning and sequencing alleles of the KIR2DL4 gene from genomic DNA samples
Roberts, C. H.
Madrigal, J. A.
Marsh, S. G. E.
TISSUE ANTIGENS, 2007, 69 : 88 - 91
[35] Langerhans Cell Histiocytosis Expresses Killer Cell Immunoglobulin-Like Receptor 2DL4 (CD158d), a Possible Target of Antibody Therapy
Kataoka, Tatsuki R.
Ueshima, Chiyuki
Hirata, Masahiro
Takei, Yusuke
Iwamoto, Sanju
Haga, Hironori
LABORATORY INVESTIGATION, 2016, 96 : 356A - 356A
[36] Combined maternal KIR2DL4 and fetal HLA-G polymorphisms were associated with preeclampsia in a Han Chinese population
Ma, Yantuanjin
Qian, Yuan
Jiang, Hong
Meng, Haiyun
Wang, Yang
Yang, Yuling
FRONTIERS IN GENETICS, 2024, 15
[37] The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated
Gómez-Lozano, N
Estefanía, E
Williams, F
Halfpenny, I
Middleton, D
Solís, R
Vilches, C
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (01) : 16 - 24
[38] KIR2DL4 allelic polymorphism in French and Congolese populations by cloning-sequencing
Buhler, Stephane
Di Cristofaro, Julie
Frassati, Coralie
Basire, Agnes
Galicher, Vital
Chiaroni, Jacques
Picard, Christophe
TISSUE ANTIGENS, 2009, 73 (05): : 480 - 480
[39] Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells
Li, Guangjin
Weyand, Cornelia M.
Goronzy, Joerg J.
JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (03) : 824 - 834
[40] Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment
Zheng, Guoxu
Jia, Lintao
Yang, An-Gang
FRONTIERS IN IMMUNOLOGY, 2022, 13

← 1 2 3 4 5 →