A dual-response ratiometric fluorescent probe for hypochlorite and hydrazine detection and its imaging in living cells

被引：37
|
作者：
Wang, Lin [1 ]
Pan, Qi [2 ]
Chen, Yuan [2 ]
Ou, Yunfu [1 ]
Li, Huanyong [1 ]
Li, Bowen [2 ]
机构：
[1] Jinan Univ, Analyt & Testing Ctr, Guangzhou 510632, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2020年 / 241卷 / 241期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Ratiometric fluorescent; Carbazole; Hypochlorite detection; Hydrazine detection; Cell imaging; TURN-ON; SELECTIVE VISUALIZATION; MITOCHONDRIA; CHEMOSENSOR; ACID; AL3+; RECOGNITION;
D O I：
10.1016/j.saa.2020.118672
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
In this work, a dual-response ratiometric fluorescent probe (E)-3-(5-(2-nitrovinyl)thiophen-2-yl)-9-phenyl-9H-carbazole (NTPC) for high selectivity and sensitivity detection of ClO- and N2H4 was successfully developed. This probe NTPC showed ratiometric fluorescent response to ClO- and N2H4, which induces obvious naked-eye color changes, respectively. In addition, the NTPC for ClO- and N2H4 detection displayed low detection limits of 71.4 nM and 0.6 mu M, respectively. And the sensing mechanism of NTPC with ClO- and N2H4 was well confirmed by H-1 NMR and HR-MS spectra. Moreover, this novel probe was applied to monitoring and differentiating ClO- and N2H4 in living cells, and exhibits good biocompatibility and low cytotoxicity. (C) 2020 Elsevier B.V. All rights reserved.
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页数：7
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