Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart

被引：46
|
作者：
Montero, JA
Giron, B
Arrechedera, H
Cheng, YC
Scotting, P
Chimal-Monroy, J
Garcia-Porrero, JA
Hurle, JM [1 ]
机构：
[1] Univ Cantabria, Fac Med, Dept Anat & Biol Celular, Santander 39011, Spain
[2] Univ Nottingham, Genet Inst, Nottingham NG7 2UH, England
[3] Cent Univ Venezuela, Fac Med, Inst Trop Med, Caracas, Venezuela
[4] Univ Nottingham, Inst Genet, Nottingham NG7 2UH, England
来源：
MECHANISMS OF DEVELOPMENT | 2002年 / 118卷 / 1-2期
关键词：
Sox8; Sox9; Sox10; embryonic heart; chick embryo; aggrecan;
D O I：
10.1016/S0925-4773(02)00249-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We describe the expression pattern of Sox8, Sox9 and Sox10 during the development of the chick embryo heart. These Sox genes constitute the group E of the large Sox family of transcription factors. We show that the expression of Sox8, Sox9 and Sox10 in the developing heart correlates with heart septation and with the differentiation of the connective tissue of the valve leaflets. Sox10 appears also as a specific marker of developing heart nerves. These findings fit with the occurrence of morphological and functional anomalies of the heart reported in humans deficient for Sox9 and Sox10. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：199 / 202
页数：4
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