A linkage disequilibrium map of the MHC region based on the analysis of 14loci haplotypes in 50 French families

被引：63

作者：

Sanchez-Mazas, A

Djoulah, S

Busson, M

de Gouville, IL

Poirier, JC

Dehay, C

Charron, D

Excoffier, L

Schneider, S

Langaney, A

Dausset, J

Hors, J

机构：

[1] Univ Geneva, Dept Anthropol & Ecol, Lab Genet & Biometry, CH-1227 Geneva, Switzerland

[2] Musee Homme, Paris, France

[3] Hop St Louis, Dept Immunol, LNH, Paris, France

[4] Hop St Louis, INSERM, U396, Paris, France

[5] Hop St Louis, Fondat Jean Dausset, CEPH, Paris, France

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2000年 / 8卷 / 01期

关键词：

MHC; linkage disequilibrium; HLA haplotypes; French population; CEPH families; population genetics;

D O I：

10.1038/sj.ejhg.5200391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A sample of 100 individuals from 50 French families of known pedigrees were typed for 14 loci of the HLA region (DPB1, DQB1, DQA1, DRB1, DRB3,4,5, C4B, C4A, Bf, C2, TNFa, TNFb, B, Cw A). Linkage disequilibrium in each pair of loci was investigated by an exact test using a Markov chain algorithm. The results indicate no disequilibrium between DPB1 and the other loci, whereas the other class II genes are all significantly linked to each other. Linkage disequilibrium is also detected between some pairs of class I and class II-class I loci despite the long physical distance separating the loci (eg A-B, Cw-DRB1). On the other hand, some contiguous loci of the class III region are found to be in equilibrium with each other. Several hypotheses including selection, but also unequal allelic diversity at different MHC loci are discussed to explain this complex pattern of linkage disequilibrium.

引用

页码：33 / 41

页数：9

共 44 条

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