A linkage disequilibrium map of the MHC region based on the analysis of 14loci haplotypes in 50 French families

被引：63
|
作者：
Sanchez-Mazas, A
Djoulah, S
Busson, M
de Gouville, IL
Poirier, JC
Dehay, C
Charron, D
Excoffier, L
Schneider, S
Langaney, A
Dausset, J
Hors, J
机构：
[1] Univ Geneva, Dept Anthropol & Ecol, Lab Genet & Biometry, CH-1227 Geneva, Switzerland
[2] Musee Homme, Paris, France
[3] Hop St Louis, Dept Immunol, LNH, Paris, France
[4] Hop St Louis, INSERM, U396, Paris, France
[5] Hop St Louis, Fondat Jean Dausset, CEPH, Paris, France
来源：
EUROPEAN JOURNAL OF HUMAN GENETICS | 2000年 / 8卷 / 01期
关键词：
MHC; linkage disequilibrium; HLA haplotypes; French population; CEPH families; population genetics;
D O I：
10.1038/sj.ejhg.5200391
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A sample of 100 individuals from 50 French families of known pedigrees were typed for 14 loci of the HLA region (DPB1, DQB1, DQA1, DRB1, DRB3,4,5, C4B, C4A, Bf, C2, TNFa, TNFb, B, Cw A). Linkage disequilibrium in each pair of loci was investigated by an exact test using a Markov chain algorithm. The results indicate no disequilibrium between DPB1 and the other loci, whereas the other class II genes are all significantly linked to each other. Linkage disequilibrium is also detected between some pairs of class I and class II-class I loci despite the long physical distance separating the loci (eg A-B, Cw-DRB1). On the other hand, some contiguous loci of the class III region are found to be in equilibrium with each other. Several hypotheses including selection, but also unequal allelic diversity at different MHC loci are discussed to explain this complex pattern of linkage disequilibrium.
引用
收藏
页码：33 / 41
页数：9
相关论文
共 44 条
  • [21] Short tandem repeat (STR) haplotypes in HLA: an integrated 50-kb STR/linkage disequilibrium/gene map between the RING3 and HLA-B genes and identification of STR haplotype diversification in the class III region
    Igor Vorechovsky
    Jana Kralovicova
    MichaelD Laycock
    A DavidB Webster
    Steven GE Marsh
    Alejandro Madrigal
    Lennart Hammarström
    European Journal of Human Genetics, 2001, 9 : 590 - 598
  • [22] Investigation for the linkage to the 14q13-21 region in 15 French-Canadian families with Restless Legs Syndrome.
    Levchenko, A
    Xiong, L
    Desautels, A
    Riviere, JB
    Turecki, G
    Montplaisir, JY
    Rouleau, GA
    AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (05) : 476 - 476
  • [23] Short tandem repeat (STR) haplotypes in HLA:: an integrated 50-kb STR/linkage disequilibrium/gene map between the RING3 and HLA-B genes and identification of STR haplotype diversification in the class III region
    Vorechovsky, I
    Kralovicova, J
    Laycock, MD
    Webster, ADB
    Marsh, SGE
    Madrigal, A
    Hammarström, L
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (08) : 590 - 598
  • [24] Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14
    Farnir, F
    Grisart, B
    Coppieters, W
    Riquet, J
    Berzi, P
    Cambisano, N
    Karim, L
    Mni, M
    Moisio, S
    Simon, P
    Wagenaar, D
    Vilkki, J
    Georges, M
    GENETICS, 2002, 161 (01) : 275 - 287
  • [25] Linkage map construction and quantitative trait loci analysis for bolting based on a double haploid population of Brassica rapa
    Yang, Xu
    Yu, Yang-Jun
    Zhang, Feng-Lan
    Zoul, Zhi-Rong
    Zha, Xiu-Yun
    Zhang, De-Shuang
    Xu, Jia-Bing
    JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2007, 49 (05) : 664 - 671
  • [26] Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD
    Jessica Ross
    Judith Badner
    Helena Garrido
    Brooke Sheppard
    Denise A. Chavira
    Marco Grados
    Jonathan M. Woo
    Pamela Doo
    Paula Umaña
    Eduardo Fournier
    Sarah Shaw Murray
    Carol A. Mathews
    Human Genetics, 2011, 130 : 795 - 805
  • [27] Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD
    Ross, Jessica
    Badner, Judith
    Garrido, Helena
    Sheppard, Brooke
    Chavira, Denise A.
    Grados, Marco
    Woo, Jonathan M.
    Doo, Pamela
    Umana, Paula
    Fournier, Eduardo
    Murray, Sarah Shaw
    Mathews, Carol A.
    HUMAN GENETICS, 2011, 130 (06) : 795 - 805
  • [28] A wheat intervarietal genetic linkage map based on microsatellite and target region amplified polymorphism markers and its utility for detecting quantitative trait loci
    Liu, ZH
    Anderson, JA
    Hu, J
    Friesen, TL
    Rasmussen, JB
    Faris, JD
    THEORETICAL AND APPLIED GENETICS, 2005, 111 (04) : 782 - 794
  • [29] A wheat intervarietal genetic linkage map based on microsatellite and target region amplified polymorphism markers and its utility for detecting quantitative trait loci
    Z. H. Liu
    J. A. Anderson
    J. Hu
    T. L. Friesen
    J. B. Rasmussen
    J. D. Faris
    Theoretical and Applied Genetics, 2005, 111 : 782 - 794
  • [30] ANALYSIS OF THE CD3 GENE REGION AND TYPE-1 DIABETES - APPLICATION OF FLUORESCENCE-BASED TECHNOLOGY TO LINKAGE DISEQUILIBRIUM MAPPING
    PRITCHARD, LE
    KAWAGUCHI, Y
    REED, PW
    COPEMAN, JB
    DAVIES, JL
    BARNETT, AH
    BAIN, SC
    TODD, JA
    HUMAN MOLECULAR GENETICS, 1995, 4 (02) : 197 - 202
12345