Dietary short-chain fatty acids protect against type 1 diabetes

被引:56
|
作者
Wen, Li [1 ]
Wong, F. Susan [2 ]
机构
[1] Yale Univ, Sch Med, Dept Internal Med, Sect Endocrinol, New Haven, CT 06510 USA
[2] Cardiff Univ, Div Infect & Immun, Sch Med, Cardiff, S Glam, Wales
基金
英国医学研究理事会;
关键词
T-CELLS; ANTIGEN;
D O I
10.1038/ni.3730
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The short-chain fatty acids (SCFAs) acetate and butyrate, which are released from specialized diets by gut microbes, protect non-obese diabetic (NOD) mice against insulitis and slow the progression of diabetes.
引用
收藏
页码:484 / 486
页数:4
相关论文
共 50 条
  • [11] Gut microbial short-chain fatty acids and the risk of diabetes
    Lau, Wei Ling
    Vaziri, Nosratola D.
    NATURE REVIEWS NEPHROLOGY, 2019, 15 (07) : 389 - 390
  • [12] Microbiota or short-chain fatty acids: which regulates diabetes?
    Chang H Kim
    Cellular & Molecular Immunology, 2018, 15 : 88 - 91
  • [13] Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
    Caetano-Silva, Maria Elisa
    Rund, Laurie
    Hutchinson, Noah T. T.
    Woods, Jeffrey A. A.
    Steelman, Andrew J. J.
    Johnson, Rodney W. W.
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [14] The health benefits of dietary short-chain fatty acids in metabolic diseases
    Tao, Zhipeng
    Wang, Yao
    CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2025, 65 (09) : 1579 - 1592
  • [15] Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
    Maria Elisa Caetano-Silva
    Laurie Rund
    Noah T. Hutchinson
    Jeffrey A. Woods
    Andrew J. Steelman
    Rodney W. Johnson
    Scientific Reports, 13
  • [16] Short-chain fatty acids and cancer
    Li, Shan
    Duan, Yixin
    Luo, Shudi
    Zhou, Fangxin
    Wu, Qingang
    Lu, Zhimin
    TRENDS IN CANCER, 2025, 11 (02) : 154 - 168
  • [17] Reduced short-chain fatty acids and impaired glucose homeostasis in an animal model of accelerated type 1 diabetes
    Wessel, C.
    Blaut, M.
    Roden, M.
    Burkart, V.
    DIABETOLOGIA, 2019, 62 : S202 - S202
  • [18] Short-chain fatty acids in diseases
    Zhang, Dan
    Jian, Yong-Ping
    Zhang, Yu-Ning
    Li, Yao
    Gu, Li-Ting
    Sun, Hui-Hui
    Liu, Ming-Di
    Zhou, Hong-Lan
    Wang, Yi-Shu
    Xu, Zhi-Xiang
    CELL COMMUNICATION AND SIGNALING, 2023, 21 (01)
  • [19] Short-chain fatty acids in diseases
    Dan Zhang
    Yong-Ping Jian
    Yu-Ning Zhang
    Yao Li
    Li-Ting Gu
    Hui-Hui Sun
    Ming-Di Liu
    Hong-Lan Zhou
    Yi-Shu Wang
    Zhi-Xiang Xu
    Cell Communication and Signaling, 21
  • [20] Altered Gut Microbiota and Short-Chain Fatty Acids in Children with Diabetic Ketoacidosis at Onset of Type 1 Diabetes
    Ni, Yan
    Liu, Yaru
    Lin, Hu
    Dong, Guanping
    Fu, Junfen
    DIABETES, 2024, 73