Synthesis of anti-inflammatory, analgesic and COX-II inhibitory activities of indolylpyrazolines

被引：0
|
作者：
Kumar, A [1 ]
Archana
Sharma, S
Malik, N
Sharma, P
Kaushik, K
Saxena, KK
Srivastava, VK
Verma, RS
Sharma, H
Gupta, SC
Gupta, V
Agarwal, RC
机构：
[1] LLRM Med Coll, Dept Pharmacol, Div Med Chem, Meerut 250004, Uttar Pradesh, India
[2] LLRM Med Coll, Dept Pharm, Meerut 250004, Uttar Pradesh, India
[3] Hindu Coll, Dept Chem, Moradabad, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2004年 / 43卷 / 07期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some 1-[N-phenylsulphonyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazolines 7,8 and 1-[N-benzoyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3yl)]-2-pyrazolines 5,6 have been synthesized by the reaction of 3(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)-2-pyrazolines 3,4 with benzenesulphonylchloride and benzoyl chloride respectively. The compounds of this series are screened for their anti-inflammatory, analgesic and COX-II inhibitory activities and compared with standard drugs, aspirin and indomethacin. The most active compound of this series is 1-[N-phenylsulphonyl-3-(2'-phenyl-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazoline 8.
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页码：1532 / 1536
页数：5
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