Synthesis of anti-inflammatory, analgesic and COX-II inhibitory activities of indolylpyrazolines

Some 1-[N-phenylsulphonyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazolines 7,8 and 1-[N-benzoyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3yl)]-2-pyrazolines 5,6 have been synthesized by the reaction of 3(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)-2-pyrazolines 3,4 with benzenesulphonylchloride and benzoyl chloride respectively. The compounds of this series are screened for their anti-inflammatory, analgesic and COX-II inhibitory activities and compared with standard drugs, aspirin and indomethacin. The most active compound of this series is 1-[N-phenylsulphonyl-3-(2'-phenyl-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazoline 8.