Synthesis of anti-inflammatory, analgesic and COX-II inhibitory activities of indolylpyrazolines

被引：0

作者：

Kumar, A ^{[1
]}

Archana

Sharma, S

Malik, N

Sharma, P

Kaushik, K

Saxena, KK

Srivastava, VK

Verma, RS

Sharma, H

Gupta, SC

Gupta, V

Agarwal, RC

机构：

[1] LLRM Med Coll, Dept Pharmacol, Div Med Chem, Meerut 250004, Uttar Pradesh, India

[2] LLRM Med Coll, Dept Pharm, Meerut 250004, Uttar Pradesh, India

[3] Hindu Coll, Dept Chem, Moradabad, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2004年 / 43卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some 1-[N-phenylsulphonyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazolines 7,8 and 1-[N-benzoyl-3-(2'-substituted-3'-sulphonyl-5'-methoxyindol-3yl)]-2-pyrazolines 5,6 have been synthesized by the reaction of 3(2'-substituted-3'-sulphonyl-5'-methoxyindol-3'-yl)-2-pyrazolines 3,4 with benzenesulphonylchloride and benzoyl chloride respectively. The compounds of this series are screened for their anti-inflammatory, analgesic and COX-II inhibitory activities and compared with standard drugs, aspirin and indomethacin. The most active compound of this series is 1-[N-phenylsulphonyl-3-(2'-phenyl-3'-sulphonyl-5'-methoxyindol-3'-yl)]-2-pyrazoline 8.

引用

页码：1532 / 1536

页数：5

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