A stereoselective synthesis of the C13-C19 fragment of sanglifehrin A

被引：0

作者：

Hall, P ^{[1
]}

Brun, J ^{[1
]}

Denni, D ^{[1
]}

Metternich, R ^{[1
]}

机构：

[1] Novartis Pharma AG, Res, CH-4002 Basel, Switzerland

来源：

SYNLETT | 2000年 / 03期

关键词：

sanglifehrin A; beta-ketoimide; methyl ester; tellurium;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short, stereoselective route to the C13-C19 fragment of the immunosuppressant sanglifehrin A 1, is presented. The key step involves a highly diastereoselective boron aldol reaction between beta-ketoimide 11 and triisopropylsilyl propargyl aldehyde 21c.

引用

页码：315 / 318

页数：4

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