1-trifluoromethyl-1-diethoxyphosphoryl carbene:: A new synthon for the preparation of CF3-containing α-hydroxy and α-amino phosphonic acid derivatives

被引：21
|
作者：
Titanyuk, Igor D.
Vorob'eva, Daria V.
Osipov, Sergej N.
Beletskaya, Irina P.
机构：
[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia
来源：
SYNLETT | 2006年 / 09期
关键词：
diazo compounds; fluorine; aminophosphonates; hydroxyphoshonate; insertion reactions;
D O I：
10.1055/s-2006-939704
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first synthesis of diethyl 1-diazo-2,2,2-trifluoroethylphosphonate has been developed starting from readily available compounds. The synthetic utility of this compound is demonstrated via its Rh-catalyzed insertion into O-H and N-H bonds to produce CF3-substituted a-hydroxy phosphonic and alpha-amino phosphonic acid derivatives.
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页码：1355 / 1358
页数：4
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