1-trifluoromethyl-1-diethoxyphosphoryl carbene:: A new synthon for the preparation of CF3-containing α-hydroxy and α-amino phosphonic acid derivatives

被引：21

作者：

Titanyuk, Igor D.

Vorob'eva, Daria V.

Osipov, Sergej N.

Beletskaya, Irina P.

机构：

[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

来源：

SYNLETT | 2006年 / 09期

关键词：

diazo compounds; fluorine; aminophosphonates; hydroxyphoshonate; insertion reactions;

D O I：

10.1055/s-2006-939704

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of diethyl 1-diazo-2,2,2-trifluoroethylphosphonate has been developed starting from readily available compounds. The synthetic utility of this compound is demonstrated via its Rh-catalyzed insertion into O-H and N-H bonds to produce CF3-substituted a-hydroxy phosphonic and alpha-amino phosphonic acid derivatives.

引用

页码：1355 / 1358

页数：4

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