Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro

被引：21
|
作者：
Takahashi, H
Nishina, A
Kimura, H
Motoki, K
Koketsu, M
Ishihara, H
机构：
[1] Gunma Ind Technol Ctr, Maebashi, Gumma 3792147, Japan
[2] Gunma Prefectural Inst Publ Hlth & Environm Sci, Maebashi, Gumma 3710052, Japan
[3] Gifu Univ, Life Sci Res Ctr, Div Instrumental Anal, Gifu 5011193, Japan
[4] Gifu Univ, Fac Engn, Dept Chem, Gifu 5011193, Japan
来源：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2004年 / 23卷 / 03期
关键词：
tertiary selenoamide; superoxide radicals; scavenging effect; superoxide anion-scavenging activity (SOSA);
D O I：
10.1016/j.ejps.2004.04.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O-2(-.).N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC50 of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals. (C) 2004 Elsevier B.V. All rights reserved.
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页码：207 / 211
页数：5
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