Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro

被引：21

作者：

Takahashi, H

Nishina, A

Kimura, H

Motoki, K

Koketsu, M

Ishihara, H

机构：

[1] Gunma Ind Technol Ctr, Maebashi, Gumma 3792147, Japan

[2] Gunma Prefectural Inst Publ Hlth & Environm Sci, Maebashi, Gumma 3710052, Japan

[3] Gifu Univ, Life Sci Res Ctr, Div Instrumental Anal, Gifu 5011193, Japan

[4] Gifu Univ, Fac Engn, Dept Chem, Gifu 5011193, Japan

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2004年 / 23卷 / 03期

关键词：

tertiary selenoamide; superoxide radicals; scavenging effect; superoxide anion-scavenging activity (SOSA);

D O I：

10.1016/j.ejps.2004.04.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O-2(-.).N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC50 of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：207 / 211

页数：5

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