A Tug-of-War Over Methionine

被引：2
|
作者：
Xu, Ke [1 ,2 ]
Shyu, Amy [1 ,3 ]
Li, Ming O. [1 ,2 ,3 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Program Immunol, 1275 York Ave, New York, NY 10021 USA
[2] Cornell Univ, Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Grad Program, New York, NY 10065 USA
[3] Mem Sloan Kettering Canc Ctr, Louis V Gerstner Jr Grad Sch Biomed Sci, 1275 York Ave, New York, NY 10021 USA
来源：
CELL METABOLISM | 2020年 / 32卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.cmet.2020.10.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.
引用
收藏
页码：699 / 701
页数：3
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