A Tug-of-War Over Methionine

被引：2

作者：

Xu, Ke ^{[1
,2
]}

Shyu, Amy ^{[1
,3
]}

Li, Ming O. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Immunol, 1275 York Ave, New York, NY 10021 USA

[2] Cornell Univ, Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Grad Program, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Louis V Gerstner Jr Grad Sch Biomed Sci, 1275 York Ave, New York, NY 10021 USA

来源：

CELL METABOLISM | 2020年 / 32卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cmet.2020.10.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.

引用

页码：699 / 701

页数：3

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