Atomic force microscopy for dynamic observation of human erythrocytes in a microfluidic system

被引：3
|
作者：
Kuo, Feng-Jia [1 ]
Ho, Mon-Shu [1 ,2 ]
Dai, Jane [2 ]
Fan, Ming-Huisung [1 ]
机构：
[1] Natl Chung Hsing Univ, Dept Phys, Taichung 40227, Taiwan
[2] Natl Chung Hsing Univ, Inst Nanosci, Taichung 40227, Taiwan
来源：
RSC ADVANCES | 2015年 / 5卷 / 123期
关键词：
MEMBRANE; SURFACE;
D O I：
10.1039/c5ra17864a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study investigated the possibility of using atomic force microscopy (AFM) as a drug delivery system as well as a means to manipulate individual cells in an open microfluidic system for the rapid evaluation of human erythrocyte pathology in situ. We also examined the stability and biocompatibility of a patterned polydimethylsiloxane (PDMS) platform for use in conjunction with AFM. Our results demonstrate the effectiveness of integrating a microfluidic actuator with AFM technology to conduct in vitro medical analysis using only a miniscule quantity of human tissue.
引用
收藏
页码：101319 / 101326
页数：8
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