Reactivity of some pyrazole-3-carboxylic acid derivatives towards Grignard reagent

被引：0

作者：

Korkusuz, Elif ^{[1
]}

Yildirim, Ismail ^{[2
]}

机构：

[1] Erciyes Univ, Kayseri Vocat Coll, TR-38039 Kayseri, Turkey

[2] Erciyes Univ, Fac Sci, Dept Chem, TR-38039 Kayseri, Turkey

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2017年 / 56卷 / 02期

关键词：

Furan-2,3-dione; pyrazole-3-carboxylic acid; Grignard reagent; furo[3,4-c]pyrazol-6-one; substituted-1H-pyrazole; methylmagnesium chloride; CYCLIC OXALYL COMPOUNDS; 4-BENZOYL-1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID; CHLORIDE; FUNCTIONALIZATION; MECHANISM;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 1H-pyrazole-3-carboxylic acid derivatives with methylmagnesium chloride results in the formation of 1-aryl-5-phenyl-4-(1-phenyletheny1)-1H-pyrazoles 5,7, furo-pyrazolones 6, 4-substituted-3-(1-hyaroxy-l-methylethyl) -1,5-diaryl-1H-pyrazoles 8,9 and 3-acy1-4-(1-hydroxy-1-phenylethyl)-1-ary1-5-pheny1-1H-pyrazoles 11,13. The structures of all new synthesized compounds have been established by H-1, and C-13 NMR, as well as 2D COSY, FT-IR. spectroscopic data, and elemental analyses.

引用

页码：152 / 159

页数：8

共 50 条

[41] SOME BASIC DERIVATIVES OF 3-METHYLFLAVONE-8-CARBOXYLIC ACID
DARE, P
VERLICCHI, L
SETNIKAR, I
JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1960, 2 (03): : 263 - 269
[42] SYNTHESIS OF SOME DERIVATIVES OF 3-AMINOPYRAZINE-2-CARBOXYLIC ACID
PANCECHOWSKAKSEPKO, D
ZYSKOWSKA, B
JANOWIEC, M
ACTA POLONIAE PHARMACEUTICA, 1977, 34 (06): : 561 - 567
[43] DERIVATIVES OF PYRAZOLE-1-CARBOXYLIC ACID .2. SYNTHESIS OF SOME DERIVATIVES OF 4-[2-(PYRAZOLE-1-CARBOXAMIDE)-ETHYL]BENZENESULPHONAMIDE
BRZOZOWSKI, Z
MAGIELKA, S
ACTA POLONIAE PHARMACEUTICA, 1981, 38 (04): : 399 - 405
[44] INFRARED SPECTRA OF SOME CARBOXYLIC ACID DERIVATIVES
RASMUSSEN, RS
BRATTAIN, RR
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, 71 (03) : 1073 - 1079
[45] PYRAZOLE CHEMISTRY .3. SOME FUNCTIONAL-DERIVATIVES OF PYRAZOLE
KHAN, MA
RIBEIRO, J
POLISH JOURNAL OF CHEMISTRY, 1987, 61 (4-6) : 569 - 572
[46] Studies on the Reactivity of Amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carboxylic Acid Hydrazide Towards Some Reagents for Biological Evaluation
Shamroukh, Ahmed H.
Rashad, Aymn E.
Ali, Hatem S.
Awad, Samir M.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 51 (04) : 899 - 905
[47] LIGATIONAL BEHAVIOR OF A NEW PYRAZOLE-DERIVED TRIDENTATE - MIXED-LIGAND COMPLEXES OF COBALT(II) WITH 1-NITROGUANYL-5-METHYL PYRAZOLE-3-CARBOXYLIC ACID AND HETEROCYCLIC AMINES
SAHA, N
GAYEN, NC
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1980, 57 (08) : 765 - 768
[48] CONSTITUTION OF GRIGNARD REAGENT .3. CONDUCTIVITY OF SOME ETHYLMAGNESIUM COMPOUNDS
VREUGDENHIL, AD
BLOMBERG, C
RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS-JOURNAL OF THE ROYAL NETHERLANDS CHEMICAL SOCIETY, 1964, 83 (9-1): : 1096 - &
[49] ON THE DERIVATIZATION OF 3-AMINO-PYRAZOLE-4-CARBOXYLIC ACID
HANNIG, E
BEYER, G
LABAN, G
PHARMAZIE, 1986, 41 (06): : 381 - 383
[50] Cu((II)/Mn(II) Complexes Formed by Pyrazole-3-carboxylic Acid: Syntheses, Characterization and Highly Efficient Conversion of CO2 at Atmospheric Pressure
Jiang Xiu-Yan
Rong Nian-Xin
Qiu Tian-Tian
Qian Rui
Wang Yan-Zhen
He Qing-Peng
Huang Xian-Qiang
CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2017, 33 (12) : 2303 - 2310

← 1 2 3 4 5 →