Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells

被引：10

作者：

Kwon, Daeho

Choi, In-Hong

机构：

[1] Yonsei Univ, Coll Med, Dept Microbiol, Inst Immunol & Immunol Dis, Seoul 120752, South Korea

[2] Ajou Univ, Sch Med, Dept Microbiol, Seoul, South Korea

来源：

YONSEI MEDICAL JOURNAL | 2006年 / 47卷 / 04期

关键词：

astroglial cells; hydrogen peroxide; TRAIL; cyclosporin A; apoptosis; oxidative stress; neuroimmunology;

D O I：

10.3349/ymj.2006.47.4.551

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL-mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.

引用

页码：551 / 557

页数：7

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