Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells

被引：10
|
作者：
Kwon, Daeho
Choi, In-Hong
机构：
[1] Yonsei Univ, Coll Med, Dept Microbiol, Inst Immunol & Immunol Dis, Seoul 120752, South Korea
[2] Ajou Univ, Sch Med, Dept Microbiol, Seoul, South Korea
来源：
YONSEI MEDICAL JOURNAL | 2006年 / 47卷 / 04期
关键词：
astroglial cells; hydrogen peroxide; TRAIL; cyclosporin A; apoptosis; oxidative stress; neuroimmunology;
D O I：
10.3349/ymj.2006.47.4.551
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL-mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
引用
收藏
页码：551 / 557
页数：7
相关论文
共 50 条
  • [21] Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes
    Verena Zoller
    Jan-Bernd Funcke
    Julian Roos
    Meike Dahlhaus
    Muad Abd El Hay
    Karlheinz Holzmann
    Ralf Marienfeld
    Thomas Kietzmann
    Klaus-Michael Debatin
    Martin Wabitsch
    Pamela Fischer-Posovszky
    Scientific Reports, 7
  • [22] Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
    Griffith, Thomas S.
    Kucaba, Tamara A.
    O'Donnell, Michael A.
    Burns, Jennifer
    Benetatos, Christopher
    McKinlay, Mark A.
    Condon, Stephen
    Chunduru, Srinivas
    APOPTOSIS, 2011, 16 (01) : 13 - 26
  • [23] Overexpression of Bc12 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells
    Sun, SY
    Yue, P
    Zhou, JY
    Wang, YH
    Kim, HRC
    Lotan, R
    Wu, GS
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (03) : 788 - 797
  • [24] Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist
    Thomas S. Griffith
    Tamara A. Kucaba
    Michael A. O’Donnell
    Jennifer Burns
    Christopher Benetatos
    Mark A. McKinlay
    Stephen Condon
    Srinivas Chunduru
    Apoptosis, 2011, 16 : 13 - 26
  • [25] Mononuclear cytotrophoblast cells in primary culture are a source of soluble TRAIL (TNF-related apoptosis-inducing ligand)
    Bai, X.
    Williams, J. L. R.
    Greenwood, S. L.
    Baker, P. N.
    Aplin, J. D.
    Crocker, I. P.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2008, 115 (01) : 120 - 121
  • [26] Modulation of TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling by Helicobacter pylori
    Lin, Wei-Cheng
    Wu, Yi-Ying
    Tsai, Hwei-Fang
    Hsu, Ping-Ning
    JOURNAL OF IMMUNOLOGY, 2006, 176 : S126 - S126
  • [27] Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand
    Galeone, Antonella
    Brunetti, Giacomina
    Oranger, Angela
    Greco, Giovanni
    Di Benedetto, Adriana
    Mori, Giorgio
    Colucci, Silvia
    Zallone, Alberta
    Paparella, Domenico
    Grano, Maria
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 169 (04) : 296 - 304
  • [28] Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells
    Zhang, XD
    Franco, AV
    Nguyen, T
    Gray, CP
    Hersey, P
    JOURNAL OF IMMUNOLOGY, 2000, 164 (08): : 3961 - 3970
  • [29] TNF-related apoptosis inducing ligand (TRAIL) induces apoptosis in endometrial cancer cells but not in normal cells.
    Cuello, MA
    Sadarangani, A
    Kato, S
    Espinoza, N
    Owen, GI
    JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2005, 12 (02) : 161A - 162A
  • [30] The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia
    Saraei, Raedeh
    Soleimani, Masoud
    Akbari, Ali Akbar Movassaghpour
    Hagh, Majid Farshdousti
    Hassanzadeh, Ali
    Solali, Saeed
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 107 : 1010 - 1019
12345