Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells

被引：10
|
作者：
Kwon, Daeho
Choi, In-Hong
机构：
[1] Yonsei Univ, Coll Med, Dept Microbiol, Inst Immunol & Immunol Dis, Seoul 120752, South Korea
[2] Ajou Univ, Sch Med, Dept Microbiol, Seoul, South Korea
来源：
YONSEI MEDICAL JOURNAL | 2006年 / 47卷 / 04期
关键词：
astroglial cells; hydrogen peroxide; TRAIL; cyclosporin A; apoptosis; oxidative stress; neuroimmunology;
D O I：
10.3349/ymj.2006.47.4.551
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL-mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
引用
收藏
页码：551 / 557
页数：7
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