Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

被引：26
|
作者：
Abraham, RS [1 ]
David, CS [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Sch Med, Dept Immunol, Rochester, MN 55905 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(99)00060-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.
引用
收藏
页码：122 / 129
页数：8
相关论文
共 50 条
  • [41] Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice:: Dependence on HLA class II restricted TH response
    BenMohamed, L
    Krishnan, R
    Longmate, J
    Auge, C
    Low, L
    Primus, J
    Diamond, DJ
    HUMAN IMMUNOLOGY, 2000, 61 (08) : 764 - 779
  • [42] Identification of genes/pathways responsible for resistance vs susceptibility to EAE utilizing HLA class-II transgenic mice
    Mongalam, Ashutosh
    Luckey, David
    Smart, Michele
    Sarangi, Vivekananda
    Giri, Shailendra
    Rodriguez, Moses
    David, Chella
    JOURNAL OF IMMUNOLOGY, 2015, 194
  • [43] Peptide epitopes and arthritogenicity of human cartilage proteoglycan (PG) in human MHC class II transgenic mice (HLA-DR4 and HLA-DQ8)
    Sázntó, S
    Bárdos, T
    Gonda, A
    David, CS
    Mikecz, K
    Glant, TT
    ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 : 60 - 60
  • [44] HLA CLASS-II TRANSGENIC MOUSE
    HIRAYAMA, K
    IWANAGA, T
    KIMURA, A
    YASUNAMI, M
    SASAZUKI, T
    JAPANESE JOURNAL OF HUMAN GENETICS, 1988, 33 (02): : 236 - 236
  • [45] Peptide epitopes and arthritogenicity of human cartilage proteoglycan (PG) in human MHC class II transgenic mice (HLA-DR4 and HLA-DQ8)
    Szánto, S
    Bárdos, T
    Gonda, A
    Szabó, Z
    David, CS
    Mikecz, K
    Glant, TT
    TISSUE ANTIGENS, 2004, 64 (04): : 363 - 364
  • [46] Identification of immunodominant epitopes of α-gliadin in HLA-DQ8 transgenic mice following oral immunization
    Senger, S
    Maurano, F
    Mazzeo, MF
    Gaita, M
    Fierro, O
    David, CS
    Troncone, R
    Auricchio, S
    Siciliano, RA
    Rossi, M
    JOURNAL OF IMMUNOLOGY, 2005, 175 (12): : 8087 - 8095
  • [47] Role of HLA-class II genes in susceptibility and protection to multiple sclerosis-studies using HLA class II transgenic mice
    Mangalam, Ashutosh K.
    Basal, Eati
    Luckey, David
    Behrens, Marshall
    Rodriguez, Moses
    David, Chella
    ANNALS OF NEUROLOGY, 2008, 64 : S58 - S59
  • [48] Peptide-binding assays and HLA II transgenic Aβ° mice are consistent and complementary tools for identifying HLA II-restricted peptides
    Depil, S
    Angyalosi, G
    Moralès, O
    Delacre, M
    Delhem, N
    François, V
    Georges, B
    Hammer, J
    Maillère, B
    Auriault, C
    Pancré, V
    VACCINE, 2006, 24 (13) : 2225 - 2229
  • [49] HLA-RESTRICTED RECOGNITION OF VIRAL-ANTIGENS IN HLA TRANSGENIC MICE
    KIEVITS, F
    IVANYI, P
    KRIMPENFORT, P
    BERNS, A
    PLOEGH, HL
    NATURE, 1987, 329 (6138) : 447 - 449
  • [50] Immune response of HLA-DQ transgenic mice to house dust mite allergen p2: Identification of HLA-DQ restricted minimal epitopes and critical residues
    Krco, CJ
    Harders, J
    Chapoval, S
    David, CS
    CLINICAL IMMUNOLOGY, 2000, 97 (02) : 154 - 161
12345