Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

被引：26
|
作者：
Abraham, RS [1 ]
David, CS [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Sch Med, Dept Immunol, Rochester, MN 55905 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(99)00060-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.
引用
收藏
页码：122 / 129
页数：8
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