Utilization of supercritical carbon dioxide for the preparation of 3-hydroxyflavone and β-cyclodextrin complex

被引：10
|
作者：
Wang, Bo [1 ]
He, Jun [1 ]
Sun, Donghai [1 ]
Zhang, Rui [1 ]
Han, Buxing [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2006年 / 55卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
beta-cyclodextrin; inclusion complex; 3-hydroxyflavone; supercritical carbon dioxide;
D O I：
10.1007/s10847-005-9015-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solubility of 3-hydroxyflavone in water can be enhanced by forming complex with beta-cyclodextrin (beta-CD). In this study we introduced supercritical carbon dioxide as a substitute solvent to prepare 3-hydroxyflavone-beta-cyclodextrin complex. The maximum drug loading determined by UV spectroscopy in complex was 14.7 wt.%, which was comparable to that of 1: 1 complex (17.34 wt.% of 3-hydroxyflavone). The solubility of the drug loaded in the complex was better than that of pure drug in water. The enhanced solubility was attributed to the formation of the complex and the solubility of the beta-cyclodextrin in water.
引用
收藏
页码：37 / 40
页数：4
相关论文
共 50 条
  • [41] Butyl-3-methylimidazolium chloride preparation in supercritical carbon dioxide
    Zhou, ZH
    Wang, T
    Xing, HB
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2006, 45 (02) : 525 - 529
  • [42] Preparation and Performance of Supercritical Carbon Dioxide Thickener
    Liu, Bin
    Wang, Yanling
    Liang, Lei
    POLYMERS, 2021, 13 (01) : 1 - 16
  • [43] Preparation of titanium dioxide/activated carbon composites using supercritical carbon dioxide
    Tatsuda, N
    Itahara, H
    Setoyama, N
    Fukushima, Y
    CARBON, 2005, 43 (11) : 2358 - 2367
  • [44] Complex formation of cinnamaldehyde-methyl-β-cyclodextrin and muscone-methyl-β-cyclodextrin by supercritical carbon dioxide processing and sealed heating method
    Jun He
    Wenjing Li
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 63 : 61 - 68
  • [45] Complex formation of cinnamaldehyde-methyl-β-cyclodextrin and muscone-methyl-β-cyclodextrin by supercritical carbon dioxide processing and sealed heating method
    He, Jun
    Li, Wenjing
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2009, 63 (1-2) : 61 - 68
  • [46] Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution
    Ndayishimiye, John
    Popat, Amirali
    Kumeria, Tushar
    Blaskovich, Mark A. T.
    Falconer, James Robert
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 596
  • [47] Imazalil-cyclomaltoheptaose (β-cyclodextrin) inclusion complex:: preparation by supercritical carbon dioxide and 13C CPMAS and 1H NMR characterization
    Lai, S
    Locci, E
    Piras, A
    Porcedda, S
    Lai, A
    Marongiu, B
    CARBOHYDRATE RESEARCH, 2003, 338 (21) : 2227 - 2232
  • [48] Preparation of polystyrene/montmorillonite nanocomposites in supercritical carbon dioxide
    Yang, J. (yjc-dce@mail.tsinghua.edu.cn), 1600, John Wiley and Sons Inc. (98):
  • [49] SUPERCRITICAL CARBON-DIOXIDE .3. THE DECOMPOSITION OF PHENYLAZOTRIPHENYLMETHANE IN SUPERCRITICAL CARBON-DIOXIDE
    SIGMAN, ME
    LEFFLER, JE
    JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (06): : 1165 - 1167
  • [50] Preparation of Porous Polymer Monoliths in Supercritical Carbon Dioxide
    Kang, Se Ran
    Ju, Chang Sik
    KOREAN CHEMICAL ENGINEERING RESEARCH, 2005, 43 (01): : 21 - 26
12345