Utilization of supercritical carbon dioxide for the preparation of 3-hydroxyflavone and β-cyclodextrin complex

被引：10
|
作者：
Wang, Bo [1 ]
He, Jun [1 ]
Sun, Donghai [1 ]
Zhang, Rui [1 ]
Han, Buxing [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2006年 / 55卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
beta-cyclodextrin; inclusion complex; 3-hydroxyflavone; supercritical carbon dioxide;
D O I：
10.1007/s10847-005-9015-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solubility of 3-hydroxyflavone in water can be enhanced by forming complex with beta-cyclodextrin (beta-CD). In this study we introduced supercritical carbon dioxide as a substitute solvent to prepare 3-hydroxyflavone-beta-cyclodextrin complex. The maximum drug loading determined by UV spectroscopy in complex was 14.7 wt.%, which was comparable to that of 1: 1 complex (17.34 wt.% of 3-hydroxyflavone). The solubility of the drug loaded in the complex was better than that of pure drug in water. The enhanced solubility was attributed to the formation of the complex and the solubility of the beta-cyclodextrin in water.
引用
收藏
页码：37 / 40
页数：4
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