Utilization of supercritical carbon dioxide for the preparation of 3-hydroxyflavone and β-cyclodextrin complex

被引：10
|
作者：
Wang, Bo [1 ]
He, Jun [1 ]
Sun, Donghai [1 ]
Zhang, Rui [1 ]
Han, Buxing [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2006年 / 55卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
beta-cyclodextrin; inclusion complex; 3-hydroxyflavone; supercritical carbon dioxide;
D O I：
10.1007/s10847-005-9015-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The solubility of 3-hydroxyflavone in water can be enhanced by forming complex with beta-cyclodextrin (beta-CD). In this study we introduced supercritical carbon dioxide as a substitute solvent to prepare 3-hydroxyflavone-beta-cyclodextrin complex. The maximum drug loading determined by UV spectroscopy in complex was 14.7 wt.%, which was comparable to that of 1: 1 complex (17.34 wt.% of 3-hydroxyflavone). The solubility of the drug loaded in the complex was better than that of pure drug in water. The enhanced solubility was attributed to the formation of the complex and the solubility of the beta-cyclodextrin in water.
引用
收藏
页码：37 / 40
页数：4
相关论文
共 50 条
  • [1] Utilization of Supercritical Carbon Dioxide for the Preparation of 3-Hydroxyflavone and β-Cyclodextrin Complex
    Bo Wang
    Jun He
    Donghai Sun
    Rui Zhang
    Buxing Han
    Journal of inclusion phenomena and macrocyclic chemistry, 2006, 55 : 37 - 40
  • [2] Solubilities of flavone and 3-hydroxyflavone in supercritical carbon dioxide
    Uchiyama, H
    Mishima, K
    Oka, S
    Ezawa, M
    Ide, M
    Takai, T
    Park, PW
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1997, 42 (03): : 570 - 573
  • [3] Measurement of the solubilities of flavone and 3-hydroxyflavone in supercritical carbon dioxide by supercritical fluid chromatography
    Mishima, K
    Yamauchi, S
    Ito, M
    Ezawa, M
    Tanabe, D
    SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN, 1999, 6 : 176 - 181
  • [4] Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide
    Sauceau, Martial
    Rodier, Elisabeth
    Fages, Jacques
    JOURNAL OF SUPERCRITICAL FLUIDS, 2008, 47 (02): : 326 - 332
  • [5] Utilization of supercritical carbon dioxide for complex formation of ibuprofen and methyl-β-cyclodextrin
    Charoenchaitrakool, M
    Dehghani, F
    Foster, NR
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 239 (1-2) : 103 - 112
  • [6] INVESTIGATION OF MANGANESE (II)-3-HYDROXYFLAVONE COMPLEX
    MALESEV, D
    RADOVIC, Z
    JELIKICSTANKOV, M
    PHARMAZIE, 1989, 44 (12): : 863 - 863
  • [7] INVESTIGATION OF THE MOLYBDATE(II)-3-HYDROXYFLAVONE COMPLEX
    MALESEV, D
    RADOVIC, Z
    JELIKICSTANKOV, M
    MONATSHEFTE FUR CHEMIE, 1991, 122 (6-7): : 429 - 434
  • [8] INVESTIGATION OF THE URANIL(II) 3-HYDROXYFLAVONE COMPLEX
    MALESEV, D
    RADOVIC, Z
    JELIKICSTANKOV, M
    MONATSHEFTE FUR CHEMIE, 1990, 121 (6-7): : 455 - 460
  • [9] Host-guest complexation between 3-hydroxyflavone and β-cyclodextrin: Preparation, characterization and cytotoxicity studies
    Praveena, Arumugam
    Swaminathan, Meenakshisundarm
    Prabu, Samikannu
    Rajamohan, Rajaram
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 2016, 55 (04): : 435 - 440
  • [10] Preparation of borneol–methyl-β-cyclodextrin inclusion complex by supercritical carbon dioxide processing
    Jun He
    Wenjing Li
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 65 : 249 - 256
12345