Synthesis and biological evaluation of 2',3'-dideoxy-3'-fluororibofuranosyl purine nucleosides

被引：4
|
作者：
Poopeiko, NE
Khripach, NB
Kazimierczuk, Z
Balzarini, J
DeClercq, E
Mikhailopulo, IA
机构：
[1] BYELARUSSIAN ACAD SCI, INST BIOORGAN CHEM, MINSK 220141, BELARUS
[2] UNIV WARSAW, INST EXPT PHYS, PL-02089 WARSAW, POLAND
[3] UNIV CATHOLIQUE LOUVAIN, REGA INST MED RES, B-3000 LOUVAIN LA NEUVE, BELGIUM
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 7-9期
关键词：
D O I：
10.1080/07328319708006137
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of 9-(2,3-dideoxy-3-fluoro-beta-D-ribofuranosyl)-2-chloroadenine (7b) and -2-chloro-6-methoxypurine (9b), as well as the alpha-D-anomer 7a of the former and its N-7 isomer 10a is reported. Among the compounds synthesized, only the beta-D-anomer 7b displays moderate cytotoxic activity.
引用
收藏
页码：1083 / 1086
页数：4
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