Synthesis and biological evaluation of 2',3'-dideoxy-3'-fluororibofuranosyl purine nucleosides

被引：4
|
作者：
Poopeiko, NE
Khripach, NB
Kazimierczuk, Z
Balzarini, J
DeClercq, E
Mikhailopulo, IA
机构：
[1] BYELARUSSIAN ACAD SCI, INST BIOORGAN CHEM, MINSK 220141, BELARUS
[2] UNIV WARSAW, INST EXPT PHYS, PL-02089 WARSAW, POLAND
[3] UNIV CATHOLIQUE LOUVAIN, REGA INST MED RES, B-3000 LOUVAIN LA NEUVE, BELGIUM
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 7-9期
关键词：
D O I：
10.1080/07328319708006137
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of 9-(2,3-dideoxy-3-fluoro-beta-D-ribofuranosyl)-2-chloroadenine (7b) and -2-chloro-6-methoxypurine (9b), as well as the alpha-D-anomer 7a of the former and its N-7 isomer 10a is reported. Among the compounds synthesized, only the beta-D-anomer 7b displays moderate cytotoxic activity.
引用
收藏
页码：1083 / 1086
页数：4
相关论文
共 50 条
  • [31] Synthesis and anti-HIV evaluation of new 2′,3′-dideoxy-3′-thiacytidine prodrugs
    Mourier, N
    Camplo, M
    Della Bruna, GS
    Pellacini, F
    Ungheri, D
    Chermann, JC
    Kraus, JL
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2000, 19 (07): : 1057 - 1091
  • [32] Synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine: A novel hydroformylation route
    Kaldor, SW
    Fritz, JE
    Ward, JA
    TETRAHEDRON LETTERS, 1997, 38 (09) : 1509 - 1510
  • [33] SYNTHESIS OF 2',3'-DIDEOXY-3'-PIPERIDINO-D-RIBO-HEXOFURANOSYL AND 2',3'-DIDEOXY-3'-PYRROLIDINO-D-RIBO-HEXOFURANOSYL NUCLEOSIDES FROM TRI-O-ACETYL-D-GLUCAL
    WENGEL, J
    PEDERSEN, EB
    VESTERGAARD, BF
    SYNTHESIS-STUTTGART, 1992, (03): : 319 - 322
  • [34] Synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine; A unique antiviral nucleoside
    Faul, MM
    Huff, BE
    Dunlap, SE
    Frank, SA
    Fritz, JE
    Kaldor, SW
    LeTourneau, ME
    Staszak, MA
    Ward, JA
    Werner, JA
    Winneroski, LL
    TETRAHEDRON, 1997, 53 (24) : 8085 - 8104
  • [35] Synthesis of the antiviral nucleoside 2',3'-dideoxy-3'-hydroxymethylcytidine.
    Brennan, J
    Dunlap, SE
    Faul, MM
    Frank, SA
    Fritz, JE
    Huff, BE
    Kaldor, SW
    LeTourneau, ME
    Miller, WD
    Sullivan, KA
    Staszak, MA
    Ward, JA
    Werner, JA
    Winneroski, LL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 185 - ORGN
  • [36] SYNTHESIS OF 2',3'-DIDEOXY-3'-FLUORO-D-RIBOFURANOSYL BENZIMIDAZOLE - A NEW FLUOROSUGAR PURINE NUCLEOSIDE ANALOG
    DYATKINA, NB
    ALEXANDROVA, LA
    ZEITSCHRIFT FUR CHEMIE, 1985, 25 (05): : 180 - 180
  • [37] Design, synthesis, and biological evaluation of novel iso-D-2,3′-dideoxy-3′-fluorothianucleoside derivatives
    Kim, Kyung Ran
    Moon, Hyung Ryong
    Park, Ah-Young
    Chun, Moon Woo
    Jeong, Lak Shin
    BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (01) : 227 - 234
  • [38] SYNTHESIS AND BIOLOGICAL EVALUATION OF 2'-3'-DIDEOXY-2'-FLUORO-3'-C-HYDROXYMETHYL-SUBSTITUTED NUCLEOSIDES
    CHOI, YS
    LEE, K
    LEE, CK
    LEE, CO
    CHUN, MW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 196 - MEDI
  • [39] SYNTHESIS OF 3'-CYANO-2',3'-DIDEOXYADENOSINE AND 2',3'-DIDEOXY-3'-FORMYLADENOSINE
    YU, D
    DALARCAO, M
    JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (13): : 3240 - 3242
  • [40] STEREOSELECTIVE SYNTHESIS OF 2',3'-DIDEOXY-NUCLEOSIDES AND 2,3'-DIDEHYDRO-2',3'-DIDEOXY-NUCLEOSIDES
    CHU, CK
    BEACH, JW
    BABU, JR
    JEONG, LS
    JEONG, HK
    AHN, SK
    ISLAM, Q
    LEE, SJ
    CHEN, YQ
    NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3): : 423 - 426
12345