Transglycosylation reaction of 6-thioguanosine

被引：2

作者：

Manikowski, A ^{[1
]}

Boryski, J ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 11-12期

关键词：

D O I：

10.1080/07328319908044613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peracetylated 6-thioguanosine (2) undergoes the so far unknown N-->S transglycosylation reaction to form a stable 9,S-6-bis(ribosyl) derivative (3) and N-2-acetyl-6-thioguanine (4). The reaction takes place at elevated temperatures with no catalyst, or in solution in the presence of acidic catalysts. The reversible 7 reversible arrow 9 isomerization, characteristic for guanosine and its analogs, has not been observed in this case.

引用

页码：2367 / 2377

页数：11

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