Transglycosylation reaction of 6-thioguanosine

被引：2
|
作者：
Manikowski, A [1 ]
Boryski, J [1 ]
机构：
[1] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland
来源：
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 11-12期
关键词：
D O I：
10.1080/07328319908044613
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peracetylated 6-thioguanosine (2) undergoes the so far unknown N-->S transglycosylation reaction to form a stable 9,S-6-bis(ribosyl) derivative (3) and N-2-acetyl-6-thioguanine (4). The reaction takes place at elevated temperatures with no catalyst, or in solution in the presence of acidic catalysts. The reversible 7 reversible arrow 9 isomerization, characteristic for guanosine and its analogs, has not been observed in this case.
引用
收藏
页码：2367 / 2377
页数：11
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