SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL BENZOFURAN ESTER DERIVATIVES

被引：0
|
作者：
Vakharia, Jyot [1 ]
Gangan, Vijay D. [2 ]
Chakraborty, Chaitaly T. [2 ]
Bhawe, Vijay G. [1 ]
Bhalekar, Satish M. [3 ]
机构：
[1] Bhavans Coll Arts Sci & Commerce, Dept Chem, Bombay 400058, Maharashtra, India
[2] Thakur Coll Sci & Commerce, Dept Chem, Bombay 400101, Maharashtra, India
[3] SIWS Coll, Dept Chem, Bombay 400031, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 23卷 / 03期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methyl (E)-3-[2-(4-hydroxy-3-methoxy phenyl)-7-methoxy-3-methoxycarbonyl-2,3dihydro-1-benzofuran-5-yl] prop-2-enoate constitute a new group of antimitotic and potential anticancer agents that inhibit tubulin polymerization. It is a benzofuranoid type neolignan that have been synthesized and diversified to its respective ester (Pyridine/DCM/Acetyl/Benzoyl chloride) derivatives using conventional method and characterized by H-1 NMR, IR, elemental analysis and mass spectral data. These synthesized compounds were screened for their antibacterial activity against Gram positive and Gram negative cultures. Few of them possess promising antibacterial activity.
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页码：315 / 320
页数：6
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