Inhibitory effect of Poria cocos on 12-O-tetradecanoylphorbol-13-acetate-induced ear oedema and tumour promotion in mouse skin

被引：0
|
作者：
Kaminaga, T
Yasukawa, K
Takido, M
Tai, T
Nunoura, Y
机构：
[1] NIHON UNIV,COLL PHARM,FUNABASHI,CHIBA 274,JAPAN
[2] KOTARO PHARMACEUT CO LTD,CENT RES LAB,TAKATSUKI,OSAKA 569,JAPAN
来源：
PHYTOTHERAPY RESEARCH | 1996年 / 10卷 / 07期
关键词：
Poria cocos; lanostane-type triterpene acid; 3,4-secolanostane-type triterpene acid; antitumour promotion; two-stage carcinogenesis; TPA-induced inflammation; antiinflammatory effect;
D O I：
10.1002/(SICI)1099-1573(199611)10:7<581::AID-PTR907>3.0.CO;2-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The methanol extract from the sclerotium of Poria cocos was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumour promotion in two-stage carcinogenesis in mouse skin, From the active fraction of the extract, eight lanostane-type triterpene acids and four 3,4-secolanostane-type triterpene acids were isolated, The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory oedema, The 50% inhibitory dose of pachymic acid, 3-O-acetyl-16 alpha-hydroxytrametenolic acid, dehydropachymic acid, dehydroeburiconic acid, 3 beta-hydroxylanosta-7,9(11),24-trien-21-oic acid, poricoic acid A and poricoic acid B for TPA-induced inflammation was 17-44 mu g/ear, at a grade corresponding to that of hydrocortisone.
引用
收藏
页码：581 / 584
页数：4
相关论文
共 50 条
  • [31] Cancer chemoprevention:: inhibitory effect of soybeans fermented with basidiomycetes on 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate-induced mouse skin carcinogenesis
    Shon, YH
    Nam, KS
    BIOTECHNOLOGY LETTERS, 2002, 24 (12) : 1005 - 1010
  • [32] Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis
    Huang, MT
    Ma, W
    Yen, P
    Xie, JG
    Han, JK
    Frenkel, K
    Grunberger, D
    Conney, AH
    CARCINOGENESIS, 1997, 18 (01) : 83 - 88
  • [33] Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells
    Huang, MT
    Ma, W
    Yen, P
    Xie, JG
    Han, JK
    Frenkel, K
    Grunberger, D
    Conney, AH
    CARCINOGENESIS, 1996, 17 (04) : 761 - 765
  • [34] Interleukin-12-deficiency enhances 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor promotion and malignant progression of papillomas to carcinomas in DMBA-initiated mouse skin
    Katiyar, S. K.
    Katiyar, N.
    Xu, H.
    Meeran, S. M.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 : S25 - S25
  • [35] Effect of black tea theaflavins and related benzotropolone derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced mouse ear inflammation and inflammatory mediators.
    Ramji, D
    Sang, SM
    Liu, Y
    Rosen, RT
    Ghai, G
    Ho, CT
    Yang, CS
    Huang, MT
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U57 - U57
  • [36] 3,3′-Diindolylmethane Suppresses 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammation and Tumor Promotion in Mouse Skin via the Downregulation of Inflammatory Mediators
    Kim, Eun Ji
    Park, Heesook
    Kim, Jongdai
    Park, Jung Han Yoon
    MOLECULAR CARCINOGENESIS, 2010, 49 (07) : 672 - 683
  • [37] INHIBITORY EFFECT OF SOME OXYGENATED STIGMASTANE-TYPE STEROLS ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED INFLAMMATION IN MICE
    KIMURA, Y
    YASUKAWA, K
    TAKIDO, M
    AKIHISA, T
    TAMURA, T
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1995, 18 (11) : 1617 - 1619
  • [38] Inhibitory effects of Momordica grosvenori Swingle extracts on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mouse skin
    Weerawatanakorn, Monthana
    Yang, Ji-Rui
    Tsai, Mei-Ling
    Lai, Ching-Shu
    Ho, Chi-Tang
    Pan, Min-Hsiung
    FOOD & FUNCTION, 2014, 5 (02) : 257 - 264
  • [39] INHIBITION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED NITROBLUE TETRAZOLIUM REDUCTION IN MOUSE PERITONEAL-MACROPHAGES BY VARIOUS TUMOR PROMOTION INHIBITORS
    OHKAWA, Y
    IWATA, K
    SHIBUYA, H
    INUI, N
    CANCER LETTERS, 1985, 27 (01) : 45 - 52
  • [40] Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes
    Murakami, A
    Kuki, W
    Takahashi, Y
    Yonei, H
    Nakamura, Y
    Ohto, Y
    Ohigashi, H
    Koshimizu, K
    JAPANESE JOURNAL OF CANCER RESEARCH, 1997, 88 (05): : 443 - 452
12345