Inhibitory effect of Poria cocos on 12-O-tetradecanoylphorbol-13-acetate-induced ear oedema and tumour promotion in mouse skin

被引：0
|
作者：
Kaminaga, T
Yasukawa, K
Takido, M
Tai, T
Nunoura, Y
机构：
[1] NIHON UNIV,COLL PHARM,FUNABASHI,CHIBA 274,JAPAN
[2] KOTARO PHARMACEUT CO LTD,CENT RES LAB,TAKATSUKI,OSAKA 569,JAPAN
来源：
PHYTOTHERAPY RESEARCH | 1996年 / 10卷 / 07期
关键词：
Poria cocos; lanostane-type triterpene acid; 3,4-secolanostane-type triterpene acid; antitumour promotion; two-stage carcinogenesis; TPA-induced inflammation; antiinflammatory effect;
D O I：
10.1002/(SICI)1099-1573(199611)10:7<581::AID-PTR907>3.0.CO;2-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The methanol extract from the sclerotium of Poria cocos was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumour promotion in two-stage carcinogenesis in mouse skin, From the active fraction of the extract, eight lanostane-type triterpene acids and four 3,4-secolanostane-type triterpene acids were isolated, The isolated compounds showed inhibitory activity against TPA-induced ear inflammatory oedema, The 50% inhibitory dose of pachymic acid, 3-O-acetyl-16 alpha-hydroxytrametenolic acid, dehydropachymic acid, dehydroeburiconic acid, 3 beta-hydroxylanosta-7,9(11),24-trien-21-oic acid, poricoic acid A and poricoic acid B for TPA-induced inflammation was 17-44 mu g/ear, at a grade corresponding to that of hydrocortisone.
引用
收藏
页码：581 / 584
页数：4
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