Towards an electrowetting-based digital microfluidic platform for magnetic immunoassays

被引：16

作者：

Schaller, Vincent ^{[1
]}

Sanz-Velasco, Anke ^{[1
]}

Kalabukhov, Alexey ^{[1
]}

Schneiderman, Justin F. ^{[1
]}

Oisjoen, Fredrik ^{[1
]}

Jesorka, Aldo ^{[2
]}

Astalan, Andrea Prieto ^{[3
]}

Krozer, Anatol ^{[3
]}

Rusu, Cristina ^{[3
]}

Enoksson, Peter ^{[1
]}

Winkler, Dag ^{[1
]}

机构：

[1] Chalmers, Dept Microtechnol & Nanosci MC2, SE-41296 Gothenburg, Sweden

[2] Chalmers, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden

[3] Imego Inst, SE-40014 Gothenburg, Sweden

来源：

LAB ON A CHIP | 2009年 / 9卷 / 23期

关键词：

ON-A-CHIP; LIQUID DROPLETS; NANOPARTICLES; ACTUATION; PARTICLES;

D O I：

10.1039/b912646e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We demonstrate ElectroWetting-On-Dielectric (EWOD) transport and SQUID gradiometer detection of magnetic nanoparticles (MNPs) suspended in a 2 mu l de-ionized water droplet. This proof-of-concept methodology constitutes the first development step towards a highly sensitive magnetic immunoassay platform with SQUID readout and droplet-based sample handling. Magnetic AC-susceptibility measurements were performed on MNPs with a hydrodynamic diameter of 100 nm using a high-Tc dc Superconducting Quantum Interference Device (SQUID) gradiometer as detector. We observed that the signal amplitude per unit volume is 2.5 times higher for a 2 ml sample droplet compared to a 30 ml sample volume.

引用

页码：3433 / 3436

页数：4

共 50 条

[31] Electrowetting-Based Variable Tuning Prism
Terrab, Soraya
Watson, Alexander M.
Dease, Kevin
Gopinath, Juliet T.
Bright, Victor M.
2015 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO), 2015,
[32] Electrowetting-based measurement of interfacial tension
Choi, Seungyul
Kwon, Yongjoo
Lee, Junghoon
APPLIED PHYSICS LETTERS, 2014, 105 (18)
[33] Electrowetting-based liquid lenses for endoscopy
Kuiper, S.
MOEMS AND MINIATURIZED SYSTEMS X, 2011, 7930
[34] Control of an electrowetting-based beam deflector
de Boer, Bart
Suijver, Freek
Megens, Mischa
Deladi, Szabolcs
Kuiper, Stein
JOURNAL OF APPLIED PHYSICS, 2010, 107 (06)
[35] Deformation, speed, and stability of droplet motion in closed electrowetting-based digital microfluidics
Guan, Yin
Li, Baiyun
Zhu, Mengnan
Cheng, Shengjie
Tu, Jiyue
PHYSICS OF FLUIDS, 2019, 31 (06)
[36] Invited paper: Electrowetting-based information displays
Hayes, Robert A.
2008 SID INTERNATIONAL SYMPOSIUM, DIGEST OF TECHNICAL PAPERS, VOL XXXIX, BOOKS I-III, 2008, 39 : 651 - 654
[37] A novel electrode shape for electrowetting-based microfluidics
Rajabi, Negar
Dolatabadi, Ali
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2010, 365 (1-3) : 230 - 236
[38] Electrowetting-based actuation of droplets for integrated microfluidics
Pollack, MG
Shenderov, AD
Fair, RB
LAB ON A CHIP, 2002, 2 (02): : 96 - 101
[39] An improved crescent electrode in electrowetting-based microfludic
Jin, Hongli
2016 6TH IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (IEEE 3M-NANO), 2016, : 295 - 298
[40] Accelerated electrowetting-based tunable fluidic lenses
Zhao, Pengpeng
Li, Yang
Zappe, Hans
OPTICS EXPRESS, 2021, 29 (10): : 15733 - 15746

← 1 2 3 4 5 →