Visible-Light-Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2-Trifluoromethyl Quinolines

被引：51

作者：

Dong, Xichang ^{[1
]}

Xu, Youwei ^{[1
]}

Liu, Jing Jing ^{[1
]}

Hu, Yumin ^{[1
]}

Xiao, Tiebo ^{[1
]}

Zhou, Lei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 50期

基金：

中国国家自然科学基金;

关键词：

cyclization; photocatalysis; quinolines; radicals; visible light; C-H FUNCTIONALIZATION; ALPHA-AMINOALKYL RADICALS; PHOTOREDOX CATALYSIS; EFFICIENT SYNTHESIS; ELECTRON-TRANSFER; ORGANIC-REACTIONS; IMIDOYL RADICALS; BOND FORMATIONS; AQUEOUS-MEDIA; TRIPLE BOND;

D O I：

10.1002/chem.201303149

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient method for the synthesis of 2-trifluoromethyl quinolines by means of visible-light-induced radical cyclization of trifluoroacetimidoyl chlorides with alkynes has been developed. This protocol allows the generation of imidoyl radicals by activation of C(sp 2)ï£¿Cl bonds using a photoredox catalyst under mild and environmentally friendly conditions (see scheme). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：16928 / 16933

页数：6

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