Visible-Light-Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2-Trifluoromethyl Quinolines

被引：51
|
作者：
Dong, Xichang [1 ]
Xu, Youwei [1 ]
Liu, Jing Jing [1 ]
Hu, Yumin [1 ]
Xiao, Tiebo [1 ]
Zhou, Lei [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 50期
基金：
中国国家自然科学基金;
关键词：
cyclization; photocatalysis; quinolines; radicals; visible light; C-H FUNCTIONALIZATION; ALPHA-AMINOALKYL RADICALS; PHOTOREDOX CATALYSIS; EFFICIENT SYNTHESIS; ELECTRON-TRANSFER; ORGANIC-REACTIONS; IMIDOYL RADICALS; BOND FORMATIONS; AQUEOUS-MEDIA; TRIPLE BOND;
D O I：
10.1002/chem.201303149
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and efficient method for the synthesis of 2-trifluoromethyl quinolines by means of visible-light-induced radical cyclization of trifluoroacetimidoyl chlorides with alkynes has been developed. This protocol allows the generation of imidoyl radicals by activation of C(sp 2)Cl bonds using a photoredox catalyst under mild and environmentally friendly conditions (see scheme). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：16928 / 16933
页数：6
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