An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl2-Catalyzed Three-Component Coupling Reaction

被引：113

作者：

Sasada, Toshiaki ^{[1
]}

Kobayashi, Fuminori ^{[1
]}

Sakai, Norio ^{[1
]}

Konakahara, Takeo ^{[1
]}

机构：

[1] Tokyo Univ Sci, RIKADAI, Dept Pure & Appl Chem, Fac Sci & Technol, Chiba 2788510, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 10期

关键词：

ONE-POT SYNTHESIS; N-HETERO COMPOUNDS; SUBSTITUTED PYRIMIDINES; RING TRANSFORMATION; EFFICIENT SYNTHESIS; AROMATIC NITRILES; STEP SYNTHESIS; CYCLIZATION; GENERATION; PALLADIUM;

D O I：

10.1021/ol900382j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a ZnCl2-catatyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pydmidine derivatives, using methyl ketone derivatives instead of enamines.

引用

页码：2161 / 2164

页数：4

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