Synthesis of 4′-aryl-2′,3′-dideoxynucleoside analogues

被引：19
|
作者：
Jogi, Artur [1 ]
Paju, Anne [1 ]
Pehk, Tonis [2 ]
Kailas, Tiiu [1 ]
Mueuerisepp, Aleksander-Mati [1 ]
Lopp, Margus [1 ]
机构：
[1] Tallinn Univ Technol, Fac Sci, Dept Chem, EE-19086 Tallinn, Estonia
[2] NICPB, EE-12618 Tallinn, Estonia
来源：
TETRAHEDRON | 2009年 / 65卷 / 15期
关键词：
ANTI-HIV ACTIVITY; ASYMMETRIC-SYNTHESIS; ANTICANCER EVALUATION; DNA-SYNTHESIS; TETRAHYDROFURAN; NUCLEOSIDE; LIGNAN; AGENT;
D O I：
10.1016/j.tet.2009.02.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 4'-aryl-2',3'-dideoxynucleoside analogues were synthesized from optically pure 5-oxo-2-aryltetrahydrofuran-2-carboxylic acids up to 62% overall yield, 5-Oxo-2-aryl-tetrahydrofuran-2-carboxylic acids were obtained from 2-hydroxy-3-arylcyclopent-2-en-1-ones by asymmetric oxidation in up to 38-57% yield. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2959 / 2965
页数：7
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