Synthesis of 4′-aryl-2′,3′-dideoxynucleoside analogues

被引：19

作者：

Jogi, Artur ^{[1
]}

Paju, Anne ^{[1
]}

Pehk, Tonis ^{[2
]}

Kailas, Tiiu ^{[1
]}

Mueuerisepp, Aleksander-Mati ^{[1
]}

Lopp, Margus ^{[1
]}

机构：

[1] Tallinn Univ Technol, Fac Sci, Dept Chem, EE-19086 Tallinn, Estonia

[2] NICPB, EE-12618 Tallinn, Estonia

来源：

TETRAHEDRON | 2009年 / 65卷 / 15期

关键词：

ANTI-HIV ACTIVITY; ASYMMETRIC-SYNTHESIS; ANTICANCER EVALUATION; DNA-SYNTHESIS; TETRAHYDROFURAN; NUCLEOSIDE; LIGNAN; AGENT;

D O I：

10.1016/j.tet.2009.02.010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 4'-aryl-2',3'-dideoxynucleoside analogues were synthesized from optically pure 5-oxo-2-aryltetrahydrofuran-2-carboxylic acids up to 62% overall yield, 5-Oxo-2-aryl-tetrahydrofuran-2-carboxylic acids were obtained from 2-hydroxy-3-arylcyclopent-2-en-1-ones by asymmetric oxidation in up to 38-57% yield. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2959 / 2965

页数：7

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