Purification Methodology for Viable and Infective Plasmodium vivax Gametocytes That Is Compatible with Transmission-Blocking Assays

被引：9
|
作者：
Vera, Omaira [1 ,2 ]
de Brito, Paula Brelas [2 ]
Albrecht, Letusa [1 ,3 ]
Monick Martins-Campos, Keillen [2 ,4 ]
Pimenta, Paulo F. P. [5 ]
Monteiro, Wuelton M. [2 ,4 ]
Lacerda, Marcus V. G. [2 ,6 ]
Lopes, Stefanie C. P. [1 ,2 ,6 ]
Costa, Fabio T. M. [1 ]
机构：
[1] Univ Estadual Campinas, UNICAMP, Dept Genet Evolucao & Bioagentes, Sao Paulo, Brazil
[2] Fundacao Med Trop Dr Heitor Vieira Dourado, Gerencia Malaria, Manaus, Amazonas, Brazil
[3] Fiocruz MS, Fundacao Oswaldo Cruz, Inst Carlos Chagas, Curitiba, Parana, Brazil
[4] Univ Estado Amazonas, Escola Super Ciencias Saude, Manaus, Amazonas, Brazil
[5] Fiocruz MS, Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil
[6] Fiocruz MS, Fundacao Oswaldo Cruz, Inst Leonidas Maria Deane, Manaus, Amazonas, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 10期
基金：
巴西圣保罗研究基金会;
关键词：
MALARIA; BLOOD;
D O I：
10.1128/AAC.01136-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Significant progress toward the control of malaria has been achieved, especially regarding Plasmodium falciparum infections. However, the unique biology of Plasmodium vivax hampers current control strategies. The early appearance of P. vivax gametocytes in the peripheral blood and the impossibility of culturing this parasite are major drawbacks. Using blood samples from 40 P. vivax-infected patients, we describe here a methodology to purify viable gametocytes and further infect anophelines. This method opens new avenues to validate transmission-blocking strategies.
引用
收藏
页码：6638 / 6641
页数：4
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