Therapeutic and Transmission-Blocking Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

被引：13
|
作者：
Popovici, Jean [1 ]
Vantaux, Amelie [1 ]
Primault, Lyse [1 ]
Samreth, Reingsey [1 ]
Piv, Eak Por [1 ]
Bin, Sophalai [1 ]
Kim, Saorin [1 ]
Lek, Dysoley [2 ]
Serre, David [3 ]
Menard, Didier [1 ,4 ]
机构：
[1] Inst Pasteur, Phnom Penh, Cambodia
[2] Natl Ctr Malaria Control, Phnom Penh, Cambodia
[3] Univ Maryland, Sch Med, Baltimore, MD 21201 USA
[4] Inst Pasteur, Paris, France
来源：
EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 08期
基金：
美国国家卫生研究院;
关键词：
RANDOMIZED-TRIAL; PIPERAQUINE;
D O I：
10.3201/eid2408.170768
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >= 2 months.
引用
收藏
页码：1516 / 1519
页数：4
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