Therapeutic and Transmission-Blocking Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

被引：13

作者：

Popovici, Jean ^{[1
]}

Vantaux, Amelie ^{[1
]}

Primault, Lyse ^{[1
]}

Samreth, Reingsey ^{[1
]}

Piv, Eak Por ^{[1
]}

Bin, Sophalai ^{[1
]}

Kim, Saorin ^{[1
]}

Lek, Dysoley ^{[2
]}

Serre, David ^{[3
]}

Menard, Didier ^{[1
,4
]}

机构：

[1] Inst Pasteur, Phnom Penh, Cambodia

[2] Natl Ctr Malaria Control, Phnom Penh, Cambodia

[3] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[4] Inst Pasteur, Paris, France

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 08期

基金：

美国国家卫生研究院;

关键词：

RANDOMIZED-TRIAL; PIPERAQUINE;

D O I：

10.3201/eid2408.170768

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >= 2 months.

引用

页码：1516 / 1519

页数：4

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